Virtual Human Twin (VHT) Models for Cancer Research

Expected Outcome: Proposals under this topic should aim to deliver results that are directed and tailored towards and contribute to all of the following expected outcomes: Researchers of different disciplines use advanced multiscale Virtual Human Twins (VHTs) to expand the knowledge and understanding of cancer onset and progression Healthcare professionals and researchers have access to advanced VHT-based solutions that model cancer onset and progression over time, contributing to improve personalised treatments Researchers, healthcare professionals, innovators and citizens have access to cancer VHTs through the UNCAN.eu and the advanced Virtual Human Twin platforms Scope: Virtual human twins (VHTs) are digital representations and in-silico models of an individual’s health and disease at different levels of the human anatomy (e.g. cells, tissues, organs or organ systems) for the prevention, prediction, screening, diagnosis and treatment of a disease, as well as the selection and personalisation of intervention options[1]. The proposed topic will contribute to the EU Cancer Mission objectives by improving the accuracy of dynamic and multiscale VHTs to better understand cancer onset, predict progression and develop personalized treatments. Of particular interest for this topic are cancers with limited treatment options or unclear biological mechanisms, refractory cancers, rare cancers, early-onset cancers, cancer types with low five-year survival rates, or paediatric and adoles…bron

• Ontwikkeling van innovatieve, dynamische multiscale VHTs voor mechanistisch begrip van kankerontwikkeling en progressie
• Integratie van AI-tools voor analyse van grote volumes FAIR multimodale data
• Validatie van VHTs met longitudinale patiëntgegevens en demonstratie van klinische bruikbaarheid
• Verrijking en beschikbaarstelling van data en modelactiva in UNCAN.eu en Advanced VHT Platform volgens open science-principes
• Samenwerking tussen verschillende wetenschappelijke disciplines, inclusief zorgprofessionals en patiënten
• Beschouwing van leeftijd-, geslachts- en genderverschillen
• Focus op kankertypen met beperkte behandelopties, refractaire kankers, zeldzame kankers, kankers met vroeg begin, of lage vijfjaarsoverlevingspercentages

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